Reacciones de trifluorometilación catalizadas por metales de transición
Transition Metal Catalyzed Trifluoromethylation Reactions
DOI:
https://doi.org/10.54167/tecnociencia.v16i1.838Palabras clave:
trifluorometilación, metales de transición, catalizadorResumen
Las reacciones de trifluorometilación tienen gran importancia en la industria farmacéutica por las propiedades que confieren a los compuestos que presentan tal grupo funcional. Este tipo de reacciones están presentes en la elaboración de sintones o unidades estructurales claves para la producción de Aprepitant, Fluoxetina, Leflunomida y Dutasterida, teniendo gran impacto en la industria farmacéutica. Se resumen los diferentes reactivos empleados en la trifluorometilación remarcando la relevancia que tienen las reacciones catalizadas por metales de transición en la obtención de procesos más baratos y limpios.
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