Co-infecciones presentes durante la pandemia por COVID-19: Revisión Sistemática
Co-infections occurring during the COVID-19 pandemic: A Sistematic Review
DOI:
https://doi.org/10.54167/tch.v16i2.974Palabras clave:
co-infección, COVID-19, infección intrahospitalaria, bacterias, hongosResumen
Se presenta una revisión sistemática sobre los patógenos de mayor prevalencia en los casos reportados de co-infección en pacientes con COVID-19 a nivel internacional. El objetivo de la revisión es reportar la prevalencia de casos de co-infección e identificar a los patógenos que la causan. A partir de las bases de datos Pubmed, Google Scholar y Scopus se obtuvieron artículos que incluyeran las palabras: “co-infección”, “infección secundaria”, “infección intrahospitalaria”, “COVID-19”, “SARS-CoV-2”, “infección bacteriana”, “infección viral”, e “infección micotica”. Posteriormente se aplicó un filtro para descartar los artículos que no cumplían los criterios de elegibilidad, lo que dio como resultado 32 artículos. A continuación, se clasificaron los casos de co-infeccion según el patógeno causante y el origen: micótico, viral o bacteriano; posteriormente se obtuvo la proporción de casos según la clasificación. Como resultado se muestra que la proporción en la prevalencia de pacientes con co-infección bacteriana fue del 1.64 %, con co-infección vírica fue del 1.00 % y con co-infección fúngica fue del 2.60 %. Aunque estos porcentajes son muy pequeños en comparación con los pacientes que sólo tienen COVID-19, es importante que el personal sanitario lleve un registro de qué patógeno está co-infectando a los pacientes con el objetivo de garantizar un tratamiento y control adecuados.
Descargas
Citas
Adalbert, J. R., Varshney, K., Tobin, R., & Pajaro, R. (2021). Clinical outcomes in patients co-infected with COVID-19 and Staphylococcus aureus: a scoping review. BMC Infectious Diseases 21(1), 1–17. https://doi.org/10.1186/s12879-021-06616-4
Adhikari, G. (2020). Intuition on virology, epidemiology, pathogenesis, and control of COVID-19. Novel Research in Microbiology Journal, 4(5), 955–967. https://doi.org/10.21608/nrmj.2020.118446
Agrifoglio, A., Cachafeiro, L., Figueira, J.C., Añón, J.M., García de Lorenzo, A. (2020) Critically ill patients with COVID-19 and candidaemia: We must keep this in mind. Journal de Mycologie Médicale 30 (4), 101012 https://doi.org/10.1016/j.mycmed.2020.101012
Agudelo-Gonzalez, S., Murcia-Sanchez, F., Salinas, D., & Osorio, J. (2015). Infecciones oportunistas en pacientes con VIH en el hospital universitario de Neiva, Colombia. 2007-2012. Infectio 19(2), 52–59. https://doi.org/10.1016/j.infect.2014.11.008
Aguilera, Y., Díaz, Y., Ortiz, L., Gonzalez, O., Lovelle, O., & Sánchez, M. (2020). Infecciones bacterianas asociadas a la COVID-19 en pacientes de una unidad de cuidados intensivos. Revista Cubana de Medicina Militar 49(3), 14. http://www.revmedmilitar.sld.cu/index.php/mil/article/view/793/539
Arnold, F. W., & Fuqua, J. L. (2020). Viral respiratory infections : a cause of community- acquired pneumonia or a predisposing factor? Current Opinion in Pulmonary Medicine: 26(3), 208–214. https://doi.org/10.1097/MCP.0000000000000666
Barrasa, H., Rello, J., Tejada, S., Martín, A., Balziskueta, G., Vinuesa, C., Fernández-Miret, B., Villagra, A., Vallejo, A., San Sebastián, A., Cabañes, S., Iribarren, S., Fonseca, F., & Maynar, J. (2020). SARS-CoV-2 in Spanish Intensive Care Units: Early experience with 15-day survival in Vitoria. Anaesthesia Critical Care and Pain Medicine, 39(5), 553–561. https://doi.org/10.1016/j.accpm.2020.04.001
Bengoechea, J. A., & Bamford, C. G. (2020). SARS ‐CoV‐2, bacterial co‐infections, and AMR : the deadly trio in COVID ‐19? . EMBO Molecular Medicine, 12(7), 10–13. https://doi.org/10.15252/emmm.202012560
Casas-Rojo JM, Antón-Santos JM, Millán-Núñez-Cortés J, Lumbreras-Bermejo C, Ramos-Rincón JM, Roy-Vallejo E, Artero-Mora A, et al. (2020). Clinical characteristics of patients hospitalized with COVID-19 in Spain: Results from the SEMI-COVID-19 Registry. Rev Clin Esp (Barc). 220(8) :480-494. https://doi.org/10.1016/j.rce.2020.07.003
Cedillos R, Cevallos N, Palou E, Sued O, Terán R, Arakaki D, Gómez B, Sereno L, V. A. (2017). Coinfección TB/VIH Guía Clínica Regional. Organización Panamericana de la Salud. https://www.apiinfectologia.org/coinfeccion-tbc-vih/
Chedid, M., Waked, R., Haddad, E., Chetata, N., Saliba, G., & Choucair, J. (2020). Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19 . The COVID-19 resource centre is hosted on Elsevier Connect , the company ’ s public news and information . January.
Chen, S., Zhu, Q., Xiao, Y., Wu, C., Jiang, Z., Liu, L., & Qu, J. (2021). Clinical and etiological analysis of co-infections and secondary infections in COVID-19 patients: An observational study. Clinical Respiratory Journal, 15(7), 815–825. https://doi.org/10.1111/crj.13369
Cimolai, N. (2021). The Complexity of Co-Infections in the Era of COVID-19. SN Comprehensive Clinical Medicine 3, 1502–1514. https://doi.org/10.1007/s42399-021-00913-4
Cox, M. J., Loman, N., Bogaert, D., & O’Grady, J. (2020). Co-infections: potentially lethal and unexplored in COVID-19. The Lancet Microbe, 1(1), e11. https://doi.org/10.1016/s2666-5247(20)30009-4
Cuadrado-Payán, E., Montagud-Marrahi, E., Torres-Elorza, M., Bodro, M., Blasco, M., Poch, E., Soriano, A., & Piñeiro, G. J. (2020). SARS-CoV-2 and influenza virus co-infection. The Lancet, 395(10236), e84. https://doi.org/10.1016/S0140-6736(20)31052-7
Cusumano, J. A., Dupper, A. C., Malik, Y., Gavioli, E. M., Banga, J., Berbel Caban, A., Nadkarni, D., Obla, A., Vasa, C. V., Mazo, D., & Altman, D. R. (2020). Staphylococcus aureus Bacteremia in Patients Infected with COVID-19: A Case Series. Open Forum Infectious Diseases, 7(11), 5–11. https://doi.org/10.1093/ofid/ofaa518
Ding, Q., Lu, P., Fan, Y., Xia, Y., & Liu, M. (2020). The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China. Journal of Medical Virology, 92(9), 1549–1555. https://doi.org/10.1002/jmv.25781
Feldman, C., & Anderson, R. (2021). The role of co-infections and secondary infections in patients with COVID-19. Pneumonia 13(5). https://doi.org/10.1186/s41479-021-00083-w
Feng, Y., Ling, Y., Bai, T., Xie, Y., Huang, J., Li, J., Xiong, W., Yang, D., Chen, R., Lu, F., Lu, Y., Liu, X., Chen, Y., Li, X., Li, Y., Summah, H. D., Lin, H., Yan, J., Zhou, M., … Qu, J. (2020). COVID-19 with different severities: A multicenter study of clinical features. American Journal of Respiratory and Critical Care Medicine 201(11), 1380–1388. https://doi.org/10.1164/rccm.202002-0445OC
González-García, J. J., Mahillo, B., Hernández, S., Pacheco, R., Diz, S., García, P., Esteban, H., Arribas, J. R., Quereda, C., Rubio, R., Díez, J., Moreno, S., & Vázquez-Rodríguez, J. J. (2005). Estudio multicéntrico sobre prevalencia de las coinfecciones por virus de hepatitis, indicación de tratamiento de hepatitis crónica C y necesidad de trasplante hepático en patientes infectados por el VIH en España. Estudio GESIDA 29/02-FIPSE 12185/01. Enfermedades Infecciosas y Microbiologia Clinica 23(6), 340–348. https://doi.org/10.1157/13076173
Gudiol, C., Durà-Miralles, X., Aguilar-Company, J., Hernández-Jiménez, P., Martínez-Cutillas, M., Fernandez-Avilés, F., Machado, M., Vázquez, L., Martín-Dávila, P., de Castro, N., Abdala, E., Sorli, L., Andermann, T. M., Márquez-Gómez, I., Morales, H., Gabilán, F., Ayaz, C. M., Kayaaslan, B., Aguilar-Guisado, M., … Carratalà, J. (2021). Co-infections and superinfections complicating COVID-19 in cancer patients: A multicentre, international study. Journal of Infection 83(3), 306–313. https://doi.org/10.1016/j.jinf.2021.07.014
Hughes, S., Troise, O., Donaldson, H., Mughal, N., & Moore, L. S. P. (2020). Bacterial and fungal coinfection amonghospitalised patients with COVID-19: a retrospective cohort study in a UK secondary-care setting. Clin Microbiol Infect 26(10):1395-1399. https://doi.org/10.1016/j.cmi.2020.06.025
Huttner, B. D., Catho, G., Pano-Pardo, J. R., Pulcini, C., & Schouten, J. (2020). COVID-19: don’t neglect antimicrobial stewardship principles! Clinical Microbiology and Infection 26(7), 808–810. https://doi.org/10.1016/j.cmi.2020.04.024
Khurana, S., Singh, P., Sharad, N., Kiro, V. V, Rastogi, N., & Lathwal, A. (2020). Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19 . The COVID-19 resource centre is hosted on Elsevier Connect , the company ’ s public news and information. January.
Kim, D., Quinn, J., Pinsky, B., Shah, N. H., & Brown, I. (2020). Rates of Co-infection between SARS-CoV-2 and Other Respiratory Pathogens. JAMA - Journal of the American Medical Association 323(20), 2085–2086. https://doi.org/10.1001/jama.2020.6266
Langford BJ, So M, Raybardhan S, Leung V, Westwood D, MacFadden DR, Soucy JR, & Daneman N. (2020). Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis. Clin Microbiol Infect. 26(12):1622-1629. https://doi.org/10.1016/j.cmi.2020.07.016
Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, K. S. M., Lau, E. H. Y., Wong, J. Y., Xing, X., Xiang, N., Wu, Y., Li, C., Chen, Q., Li, D., Liu, T., Zhao, J., Liu, M., … Feng, Z. (2020). Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia. New England Journal of Medicine 382(13), 1199–1207. https://doi.org/10.1056/nejmoa2001316
Li, Y., Wang, H., Wang, F., Lu, X., Du, H., Xu, J., Han, F., Zhang, L., & Zhang, M. (2021). Co-infections of SARS-CoV-2 with multiple common respiratory pathogens in infected children: A retrospective study. Medicine 100(11), e24315. https://doi.org/10.1097/MD.0000000000024315
Lim, Y. K., Kweon, O. J., Kim, H. R., Kim, T. H., & Lee, M. K. (2019). Impact of bacterial and viral coinfection in community-acquired pneumonia in adults. Diagnostic Microbiology and Infectious Disease 94(1), 50–54. https://doi.org/10.1016/j.diagmicrobio.2018.11.014
Liu, C., Wen, Y., Wan, W., Lei, J., & Jiang, X. (2020). Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19 . The COVID-19 resource centre is hosted on Elsevier Connect , the company ’ s public news and information . January.
Manna, S., Baindara, P., & Mandal, S. M. (2020). Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19 . The COVID-19 resource centre is hosted on Elsevier Connect , the company ’ s public news and information . January.
Mason, C. Y., Kanitkar, T., Richardson, C. J., Lanzman, M., Stone, Z., Mahungu, T., Mack, D., Wey, E. Q., Lamb, L., Balakrishnan, I., & Pollara, G. (2021). Exclusion of bacterial co-infection in COVID-19 using baseline inflammatory markers and their response to antibiotics. Journal of Antimicrobial Chemotherapy 76(5), 1323–1331. https://doi.org/10.1093/jac/dkaa563
Medicine., J. H. U. of. (2022). Coronavirus Resource Center. https://coronavirus.jhu.edu/map.html
Mirzaei, R., Goodarzi, P., Asadi, M., Soltani, A., Aljanabi, H. ali abraham, Jeda, A. S., Dashtbin, S., Jalalifar, S., Mohammadzadeh, R., Teimoori, A., Tari, K., Salari, M., Ghiasvand, S., Kazemi, S., Yousefimashouf, R., Keyvani, H., & Karampoor, S. (2020). Bacterial co-infections with SARS-CoV-2. IUBMB Life 72(10), 2097–2111. https://doi.org/10.1002/iub.2356
Musuuza, J. S., Watson, L., Parmasad, V., Putman-Buehler, N., Christensen, L., & Safdar, N. (2021). Prevalence and outcomes of co-infection and superinfection with SARS-CoV-2 and other pathogens: A systematic review and metaanalysis. PLoS ONE 16(5), e0251170. https://doi.org/10.1371/journal.pone.0251170
Nebreda-mayoral, T., Miguel-gómez, M. A., & March-rosselló, G. A. (2020). Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19 . The COVID-19 resource centre is hosted on Elsevier Connect , the company ’ s public news and information . January.
Ng, T. M., Ong, S. W. X., Loo, A. Y. X., Tan, S. H., Tay, H. L., Yap, M. Y., Lye, D. C., Lee, T. H., & Young, B. E. (2022). Antibiotic Therapy in the Treatment of COVID-19 Pneumonia: Who and When? Antibiotics 11(2), 184. https://doi.org/10.3390/antibiotics11020184
Nori, P., Cowman, K., Chen, V., Bartash, R., Szymczak, W., Madaline, T., Punjabi Katiyar, C., Jain, R., Aldrich, M., Weston, G., Gialanella, P., Corpuz, M., Gendlina, I., & Guo, Y. (2021). Bacterial and fungal coinfections in COVID-19 patients hospitalized during the New York City pandemic surge. Infection Control & Hospital Epidemiology 42(1), 84–88. https://doi.org/10.1017/ice.2020.368
Nowak, M. D., Sordillo, E. M., Gitman, M. R., & Paniz Mondolfi, A. E. (2020). Coinfection in SARS-CoV-2 infected patients: Where are influenza virus and rhinovirus/enterovirus? Journal of Medical Virology 92(10), 1699–1700. https://doi.org/10.1002/jmv.25953
Pemán, J., Ruiz-gaitán, A., García-vidal, C., & Salavert, M. (2020). Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19 . The COVID-19 resource centre is hosted on Elsevier Connect , the company ’ s public news and information . January.
Pongpirul, W. A., Mott, J. A., Woodring, J. V., Uyeki, T. M., MacArthur, J. R., Vachiraphan, A., Suwanvattana, P., Uttayamakul, S., Chunsuttiwat, S., Chotpitayasunondh, T., Pongpirul, K., & Prasithsirikul, W. (2020). Clinical Characteristics of Patients Hospitalized with Coronavirus Disease, Thailand. Emerging Infectious Diseases 26(7), 1580–1585. https://doi.org/10.3201/eid2607.200598
Prasetyoputri, A. (2021). Detection of Bacterial Coinfection in COVID-19 Patients Is a Missing Piece of the Puzzle in the COVID-19 Management in Indonesia. ACS Infect. Dis. 7 (2), 203–205. https://doi.org/10.1021/acsinfecdis.1c00006
Rajdev, K., Victor, N., Buckholtz, E. S., Hariharan, P., Saeed, M. A., Hershberger, D. M., & Bista, S. (2020). A Case of Guillain-Barré Syndrome Associated With COVID-19. Journal of Investigative Medicine High Impact Case Reports 8. https://doi.org/10.1177/2324709620961198
Rawson, T. M., Zhu, N., Ranganathan, N., Gilchrist, M., Satta, G., Cooke, G., & Holmes, A. (2020). Bacterial and fungal co-infection in individuals with coronavirus: A rapid review to support COVID-19 antimicrobial prescribing. Clinical Infectious Diseases 71(9), 2459–2468. https://doi.org/10.1093/cid/ciaa530
Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., Sigfrid, L., Harrison, E. M., Docherty, A. B., de Silva, T. I., Egan, C., Pius, R., Hardwick, H. E., Merson, L., Girvan, M., Dunning, J., Nguyen-Van-Tam, J. S., Openshaw, P. J. M., Baillie, J. K., … Young, P. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. The Lancet Microbe 2(8), e354–e365. https://doi.org/10.1016/S2666-5247(21)00090-2
Salehi, M., Ahmadikia, K., Mahmoudi, S., Kalantari, S., Jamalimoghadamsiahkali, S., Izadi, A., Kord, M., Dehghan Manshadi, S. A., Seifi, A., Ghiasvand, F., Khajavirad, N., Ebrahimi, S., Koohfar, A., Boekhout, T., & Khodavaisy, S. (2020). Oropharyngeal candidiasis in hospitalised COVID-19 patients from Iran: Species identification and antifungal susceptibility pattern. Mycoses 63(8), 771–778. https://doi.org/10.1111/myc.13137
Seaton, R. A., Gibbons, C. L., Cooper, L., Malcolm, W., Mckinney, R., Dundas, S., Griffith, D., Jeffreys, D., Hamilton, K., Choo-kang, B., Brittain, S., Guthrie, D., & Sneddon, J. (2020). Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19 . The COVID-19 resource centre is hosted on Elsevier Connect , the company ’ s public news and information . January.
Senok, A., Alfaresi, M., Khansaheb, H., Nassar, R., Hachim, M., Al Suwaidi, H., Almansoori, M., Alqaydi, F., Afaneh, Z., Mohamed, A., Qureshi, S., Ali, A., Alkhajeh, A., & Alsheikh-Ali, A. (2021). Coinfections in patients hospitalized with covid-19: A descriptive study from the United Arab Emirates. Infection and Drug Resistance 14, 2289–2296. https://doi.org/10.2147/IDR.S314029
Vaughn, V. M., Gandhi, T. N., Petty, L. A., Patel, P. K., Prescott, H. C., Malani, A. N., Ratz, D., McLaughlin, E., Chopra, V., & Flanders, S. A. (2021). Empiric Antibacterial Therapy and Community-onset Bacterial Coinfection in Patients Hospitalized with Coronavirus Disease 2019 (COVID-19): A Multi-hospital Cohort Study. Clinical Infectious Diseases 72(10), e533–e541. https://doi.org/10.1093/cid/ciaa1239
Wang, M., Wu, Q., Xu, W., Qiao, B., Wang, J., Jiang, S., Mei, J., Wu, Z., Deng, Y., Zhou, F., Wu, W., Zhang, Y., Lv, Z., Huang, J., Guo, X., Feng, L., Xia, Z., Li, D., Xu, Z., … Liu, T. (2020). Clinical diagnosis of 8274 samples with 2019-novel coronavirus in Wuhan. MedRxiv. The Preprint Server For Health Sciences. https://doi.org/10.1101/2020.02.12.20022327
Zeshan, B., Karobari, M. I., Afzal, N., Siddiq, A., Basha, S., Basheer, S. N., Peeran, S. W., Mustafa, M., Daud, N. H. A., Ahmed, N., Yean, C. Y., & Noorani, T. Y. (2022). The Usage of Antibiotics by COVID-19 Patients with Comorbidities: The Risk of Increased Antimicrobial Resistance. Antibiotics 11(1), 35. https://doi.org/10.3390/antibiotics11010035
Zhang, G., Hu, C., Luo, L., Fang, F., Chen, Y., Li, J., Peng, Z., & Pan, H. (2020). Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China. Journal of Clinical Virology 127, 104364. https://doi.org/10.1016/j.jcv.2020.104364
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., Guan, L., Wei, Y., Li, H., Wu, X., Xu, J., Tu, S., Zhang, Y., Chen, H., & Cao, B. (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet 395(10229), 1054–1062. https://doi.org/10.1016/S0140-6736(20)30566-3
Zhou, P., Liu, Z., Chen, Y., Xiao, Y., Huang, X., & Fan, X. G. (2020). Bacterial and fungal infections in COVID-19 patients: A matter of concern. Infection Control & Hospital Epidemiology 41(9), 1124–1125. https://doi.org/10.1017/ice.2020.156
Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Huang, B., Shi, W., Lu, R., Niu, P., Zhan, F., Ma, X., Wang, D., Xu, W., Wu, G., Gao, G. F., & Tan, W. (2020). A Novel Coronavirus from Patients with Pneumonia in China, 2019. New England Journal of Medicine 382(8), 727–733. https://doi.org/10.1056/nejmoa2001017
Publicado
Cómo citar
-
Resumen430
-
PDF142
-
HTML12
