Formación de partículas de polietilenglicol en presencia de calcitonina como nuevos biomateriales
Formation of poly(ethylene glycol) particles in the presence of calcitonin as new biomaterials
DOI:
https://doi.org/10.54167/tecnociencia.v1i3.59Palabras clave:
polietilenglicol, calcitonina, biomaterialesResumen
En este estudio, la formación de partículas de polietilenglicol en presencia de calcitonina de varios tamaños, es presentado. El presente trabajo tiene como objetivo mostrar una fácil ruta para la formación de nuevos biomateriales usando sistemas biológicos. La muestra de polietilenglicol fue preparada con Calcitonina; subsecuentemente, las muestras fueron sujetas a tratamiento térmico a 28° C. Las características estructurales y morfológicas fueron determinadas usando Difracción de Rayos–X, Microscopia Electrónico de Barrido, Análisis de Energía Dispersiva de Rayos-X y Microscopia Electrónico de Transmisión. Los resultados mostraron la formación de partículas con tamaños de 1 a 3 μm de diámetro. La presencia de fase cristalina no pudo ser detectada mediante difracción de rayos-X. Se observaron además, partículas de 5 nm en la estructura del compuesto. Este resultado, es importante en medicina, porque partículas de Polietilenglicol/Calcitonina pueden ser aplicadas como vehículos farmacéuticos.
Descargas
Citas
Bae, Y. H., K. M. Huh, Y. Kim & K. H. Park. 2000. Biodegradable amphiphilic multiblock copolymers and their implant for biomedical applications. Journal of Controlled Release 64(1-3):3-13. https://doi.org/10.1016/S0168-3659(99)00126-1
Beletsi, A., L. Leontiadis, P. Klepetsianis, D. S. Ithakissios & K. Avgoustakis.1999. Effect of preparative variable properties of poly(dl-lactide-co-glycolide)-methoxypoly(ethyleneglycol) copilimers related to theirs in controlled drug delivery. Int. J. Pharm. 182(2):187-197. https://doi.org/10.1016/s0378-5173(99)00058-7
Chattopadhyay, P. & R. B. Gupta. 2002. Protein nanoparticles formation by supercritical antisolvent with enhanced mass transfer. AIChE Journal 48(2):235-44. https://doi.org/10.1002/aic.690480207
Choi, Y., S. Y. Kim, S. H. Kim, K. S. Lee, C. Kim & Y. Byun. 2001. Long-term delivery of all-trans-retinoic acid using biodegradable PLLA/PEG/PLLA blended microspheres. International Journal of Pharmaceutics 215(1-2): 67-81. https://doi.org/10.1016/S0378-5173(00)00676-1
Dupont-Gillain, C. & P.G. Rouxhet. 2001. Modulable Nanometer-Scale Surface Architecture Using Spin-Coating on an Adsorbed Collagen Layer. Nano Lett. 1(5):245.251. https://doi.org/10.1021/NL010002X
Gref, R., M. Luck, P. Quellec, M. Marchand, E. Dellacherie, S. Harnisch, T. Blunk, & R.H. Müller. 2000. Stealth copolymer nanoparticles surface modified by polyethylene glycol (PEG): Influences of the corona (PEG chain surface density) and of the corecomposition on phagocytic uptake and plasma protein adsorption. Colloids and Surfaces B: Biointerfaces 18(3-4):301-313. https://doi.org/10.1016/S0927-7765(99)00156-3
Hoffman, A. S. 2002. Hydrogels for biomedical applications. Annals of the New York Academy of Sciences 944(1):62-73. https://doi.org/10.1111/j.1749-6632.2001.tb03823.x
Hrkach, J. S., M.T. Peracchia, A. Bomb, N. Lotan & R. Langer. 1997. Nanotechnology for biomaterials engineering structural characterization of amphiphilic polymeric nanoparticles by 1H NMR spectroscopy. Biomaterials 18(1):27-30. https://doi.org/10.1016/S0142-9612(96)00077-4
Huh, K., M. & Y. H. Bae. 1999. Synthesis and characterization of Poly(ethylene glycol)-poly(lactic acid) alternative multiblock copolymers. Polymer. 40:6147-6155.
Jeong, B., Y. H. Bae & S. W. Kim. 2000. Drug release from biodegradable inyectable thermosensitive hydrogel of PLGA-PEG triblock copolyemers. Journal of Controlled Release 63(1-2):155-163. https://doi.org/10.1016/s0168-3659(99)00194-7
Kim, S. R. & N. L. Abbott. 2001. Rubbed Films of Functionalized Bovine Serum Albumin as Substrates for the Imaging of Protein-Receptor Interactions Using Liquid Crystals Adv. Mater. 13(19):1445-1449. https://doi.org/10.1002/1521-4095(200110)13:19<1445::AID-ADMA1445>3.0.CO;2-9
Kissel, T., Y. Li & F. Unger. 2002. ABA- triblock copolymers from biodegradable polyester A-blocks and hydro(ethyleneoxide) B- block as a candidate for in situ forming hydrogel delivery systems for proteins. Advanced Drug Delivery Reviews 54(1):99-134. https://doi.org/10.1016/S0169-409X(01)00244-7
Kubo, M., T. Kawakatsu & T. Yonemoto. 1998. Modeling of continuous synthesis process of TIO2 particles using slugflow tubular reactor. Chemical Engineering Research and Design 76(6): 669-676. https://doi.org/10.1205/026387698525379
Li, Y. P., Y. Y. Pei, X. Y. Zhang, Z. H. Gu, Z. H. Zhou, Y. F. Yuan, J. J. Zhou, J. H. Zhu & X. J. Gao. 2001. PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats. Journal of Controlled Release 71(2): 203-211. https://doi.org/10.1016/s0168-3659(01)00218-8
Liggins, R. T. & H. M. Burt. 2002. Polyether-polyester diblock copolymers for the preparation of pacilitaxel loader polymeric micelle formulations. Adv. Drug Delivery Rev. 54(2):191-202. https://doi.org/10.1016/S0169-409X(02)00016-9
Loildl-Stahlhofen, A., J. Schmitt, J. Nöller, T. Hartmann, H. Brodowski, W. Schmitt & J. Keldenich. 2001. Solid-Supported Biomolecules on Modified Silica Surfaces – A Tool for Fast Physicochemical Characterization and High Throughput Screening. Advanced Materials 13(23):1829-34. https://doi.org/10.1002/1521-4095(200112)13:23<1829::AID-ADMA1829>3.0.CO;2-3
Mogyrosi, K., I. Dékány & J. H. Fendler. 2003. Preparation and characterization of clay mineral Intercalated titanium dioxide nanoparticles. Langmuir 19(7):2938-2946. https://doi.org/10.1021/la025969a
Morlock, M., T. Kissel, Y. X. Li, H. Koll & G. Winter. 1998. Erythropoietin loaded microspheres prepared from biodegradable LPGL-PEO-LPLG triblock copolymers: protein stabilization and in –vitro release. Journal of Controlled Release 56(1-3):105-115. https://doi.org/10.1016/S0168-3659(98)00070-4
Peytcheva, A. & M. Antonietti. 2001. “Carving on the Nanoscale”: Polymers for the Site-Specific Dissolution of Calcium. Angewandte Chemie International Edition 40(18):3380-3383. https://doi.org/10.1002/1521-3773(20010917)40:18<3380::AID-ANIE3380>3.0.CO;2-B
Sugimoto, T., K. Okada & H. Itoh. 1997. Synthetic of Uniform Spindle-Type Titania particles by the Gel-Sol. Journal of Colloid and Interface Science 193(1):140-143. https://doi.org/10.1006/jcis.1997.5037
Publicado
Cómo citar
-
Resumen334
-
PDF53
-
HTLM11
