Modelos murinos de diabetes para el estudio de compuestos bioactivos
Murine models of diabetes for the study of bioactive compounds
DOI:
https://doi.org/10.54167/tch.v18i1.1402Palabras clave:
rata diabética, ratón diabético, compuestos bioactivos, hipoglicemiante, antioxidante, antiinflamatorio, cicatrizaciónResumen
La diabetes es una enfermedad metabólica de alta prevalencia internacional. La hiperglicemia y sus complicaciones derivadas son la principal característica de la diabetes. El desarrollo de fármacos para el control glicémico y sus complicaciones ha sido del interés de la comunidad científica por muchos años y las estrategias para obtener evidencia de los efectos biológicos de las sustancias y extractos de plantas son diversas. Los modelos murinos son herramientas experimentales que permiten comprender los mecanismos fisiopatológicos de la diabetes, así como para evaluar los efectos de compuestos obtenidos de fuentes naturales, así como sintéticos sobre la hiperglicemia, el estrés oxidativo, la inflamación y la cicatrización de heridas en ratas y ratones diabéticos. En esta revisión se describen los modelos murinos para el estudio de la diabetes más frecuentemente reportados en la literatura científica actual y las estrategias que en ellos se utilizan para llevar a cabo el estudio de la actividad biológica de extractos de plantas o compuestos sintéticos.
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