Inhibitory effects of Buddleja scordioides (salvilla) leaves on digestive enzymes and carbohydrate absorption in vivo
Efectos inhibidores de las hojas de Buddleja scordioides (salvilla) sobre las enzimas digestivas y la absorción de carbohidratos in vivo
DOI:
https://doi.org/10.54167/tch.v17i2.1221Palabras clave:
planta medicinal, absorción de carbohidratos, antioxidante, Buddleja scordioidesResumen
Se evaluaron los efectos de las infusiones de hojas de Buddleja scordioides (BsLI) sobre enzimas digestivas y la absorción de carbohidratos. El rendimiento de BsLI fue del 21.64 %. Además, se caracterizarón componentes químicos: ácidos hidroxibenzoicos, ácidos hidroxicinámicos, flavonoles, flavanonas y flavonas. En estudios in vitro, se examinó cómo BsLI inhibe la lipasa, α-amilasa y α-glucosidasa. Luego, en ratas, se probó su efecto en la tolerancia oral al almidón (OSTT) a dosis de 9.5 mg/kg de peso corporal. Resultados indicaron moderada inhibición de lipasa y α-glucosidasa, y mayor inhibición de α-amilasa comparado con controles Durante la OSTT, el grupo con BsLI tuvo menor glucosa que el control negativo. Tras administrar BsLI, se detectaron compuestos bioactivos: naringenina, luteolina, quercetina y ácido cumárico. Además, BsLI fue seguro, con actividad antioxidante similar al Trolox. En conclusión, BsLI puede tener un efecto beneficioso sobre el metabolismo de la glucosa al inhibir la absorción de carbohidratos.
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